Investigate your metabolic health
*Please note Glyco-Cardio Health Report is currently only available for Women*
Concerned about metabolic disease and its impact on accelerating the ageing process?
The rate of cellular degeneration or dysfunction and at what age it begins, are areas which as clinicians, we know can be influenced, and identifying the areas that contribute to the ageing process is essential. To maintain long and healthy lives it is important to identify the main culprits of aging including consistent low-grade inflammation. This is often termed ‘inflammaging’ and is a causative factor within many ageing and degenerative disorders and identified as both a risk and an indicator of our longevity.
GlycanAge have found that in a number of conditions glycans change before onset of symptoms and even a decade before onset of disease, indicating that the loss of inflammation-suppressing IgG glycome might be casual for some.
This has been seen in Diabetes (human study) and hypertension and insulin resistance (animal study), followed by a study on 2000 twins in three time points across 15 years that indicated predictive power of IgG glycome composition for future development of hypertension (publication pending).
Our immune system keeps us alive and IgG glycome composition has been found to be associated with life expectancy in 27 different countries. Associations have also been found to correlate with the development index in the individual countries, meaning part of it is socioeconomic, even in the UK life expectancy can vary by 17 years based on your postcode (it went from 10-to-17yrs since covid).
Glycans are the most complex part of our biology “Alternative glycosylation (the attachment of different glycan structure to the same glycosylation site) is structurally and functionally analogous to coding mutations, but instead of being defined by sequence variation in individual genes, glycome composition is inherited as a complex trait encoded by multiple genes”, and unlike genes we can and influence our glycome with lifestyle change.
Extensive weight loss reduces glycan age by altering IgG N-glycosylation
To support the targeting of glycans through nutrition in the improvement of health and longevity. This study by GlycanAge demonstrates the application of Glycans as a targeted intervention: Nature – International Journal of Obesity. This is the first study that shows a significant improvement of any biological age clock with an intervention which is known to be beneficial for our health and ageing.
GlycanAge is the first biological age test that has proven responsiveness to interventions that beneficially affect the biology of ageing. Using this test in conjunction with FunctionalDX to maximise your therapeutic interventions; personalise, prioritise and progress your client’s health to the next level, reverse the ageing process, reduce the affects of dis-function and heal the body for optimal health.